As the United Kingdom's number one provider of equestrian goods, Robinsons Equestrian only stock items from the best brands on their website. One of these brands is Toggi and for many horse riders, this will be the first choice when selecting riding apparel and gear. So, with this brand receiving praise from all corners and buyers flocking to Robinsons Equestrian to take advantage of Toggi deals, why is it chosen over many other brands?
While some other brands focus purely on particular pieces of apparel, the Toggi brand specializes in all areas of equestrian leisurewear and riding apparel. Peak caps, gloves, socks and even bags can be selected from this well-known provider. In addition to this brand stocking smaller garments, buyers visiting Robinsons Equestrian can also choose from a range of quality made polo t-shirts, jackets, gilets and boots.
It is not just the vast variety of riding gear sold by Toggi that makes it stand out among other equestrian brands though, because the low prices entice buyers from everywhere. The brand has an in-depth understanding of the equestrian industry and with this knowledge; the company is able to implement what they know into their creations. As a result, buyers of all ages are satisfied with the layered styles, accessories and footwear collections sold by this successful company.
Designs are regularly updated for each season and this gives buyers a sense of trust when choosing their next equestrian wardrobe. While lighter materials are adopted for the warmer months, autumn sees Toggi introduce waterproof apparel and numerous pieces of clothing with fleece linings. Boasting a range for children too, Toggi is surely a leading brand for equestrian clothes, footwear and accessories. he brand has an in-depth understanding of the equestrian industry and with this knowledge; the company is able to implement what they know into their creations. As a result, buyers of all ages are satisfied with the layered styles, accessories and footwear collections sold by this successful company.
Designs are regularly updated for each season and this gives buyers a sense of trust when choosing their next equestrian wardrobe. While lighter materials are adopted for the warmer months, autumn sees Toggi introduce waterproof apparel and numerous pieces of clothing with fleece linings.
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On the night of the Mid-Autumn Festival, people gaze at the moon and think of their loved ones far away, who might also be gazing at the same moon. Image via EarthSky Facebook friend Lee Capps
Chinese mooncake is an traditional food for the Mid-Autumn Festival.
This mooncake is filled with a lotus seed paste. Image via Wikimedia Commons.
Sky lanterns at the Mid-Autumn Festival in Vietnam, where the festival is called Tet-Trung-Thu. Image via OhMyAsian! on Tumblr
Many Asian friends are wishing each other a happy Mid-Autumn Festival today at EarthSky?s Facebook page. For us in the U.S. and elsewhere in the Northern Hemisphere, tonight?s Harvest Moon is a sign that autumn is here. Meanwhile, in China, Taiwan, Vietnam and other parts of Asia, the focus is on the annual Mid-Autumn Festival, which by tradition also carries a strong connection to tonight?s moon. It?s sometimes called the Moon Festival in honor of this moon. It?s also called the Mooncake Festival for a traditional baked delicacy exchanged among family and friends. In 2012, the Mid-Autumn Festival takes place on September 30 for Asia and September 29 for those in the United States.
Everything you need to know: Harvest Moon 2012
The date of the Mid-Autumn Festival falls on the 15th day of the eighth month in the Chinese calendar. One website called the eighth month the Chicken month. That timing places the festival in September or early October in the Gregorian calendar, close to the autumnal equinox, every year.
This year?s autumnal equinox fell on September 22. The Chinese lunar month begins on the day of a new moon. Since the first day of eighth lunar month was September 16, 2012, the Moon Festival falls on September 30 in Asia. But it falls on September 29 in the U.S. since ? in U.S. time zones ? the date of new moon fell on September 15 for us within U.S. shores.
The Mid-Autumn Festival or Moon Festival features the beautiful idea that we all see the same moon phase on or around the same date. There are some small differences due to time zone, but, for the most part, the moon looks the same to all of us as night falls across the globe. The website Chinese-Fortune-Calendar.com said:
The Moon Festival is a holiday in China. It?s an occasion for family reunion. Chinese families like to get together to eat the mooncakes and watch the moon at the Moon Festival night. For the people are out of town or for Chinese are from China stay in USA, they miss their family or the lover at home and share the same moon at the night of the Moon Festival before the Internet gets popular.
Another tradition at the Mid-Autumn Festival is lanterns, both in the sky and on the ground. After a family dinner, Asian children are said to carry lanterns and stroll in parks or gardens. As part of the festival, lanterns are also released into the sky.
Legends associated with the Mid-Autumn Festival
And, traditionally, matchmaking has been part of the Mid-Autumn Festival. Some parts of China are said to feature dances held to help young men and women find partners, although I don?t know how widely this tradition is practiced in today?s world. According to Wikipedia:
Young women are encouraged to throw their handkerchiefs to the crowd. The young man who catches and returns the handkerchief has a chance of romance.
Bottom line: On September 29 and 30, 2012, happy Harvest Moon to friends in the western hemisphere, and to our friends in Asia ? happy Mid-Autumn Festival! This post has some photos and traditions of this Asian festival, which is also called the Moon Festival or Mooncake Festival.
The private law office of Vallejo Mayor Osby Davis caught fire overnight and fire inveistigators quickly declared the fire suspicious.?
VIdeo from the scene Saturday morning showed extensive damage in the front lobby section of the office. The back offices also suffered smoke damage, according to firefighters.
Mayor Davis arrived on the scene while the fire was still burning.?
FIrefighters said they got the call about the fire at 1:30 a.m. and when they arrived flames and smoke were pouring from the one story structure in downtown Vallejo.
Fire investigators said they are looking into the possibility of arson.?
Construction crews were on the scene by 7 a.m. with a plan to board up the building.?
Japan/Hong Kong, Whale/Tony, Belarus/Liechtenstein, Russia/America. (I could go on and on about this... AND I'M BORED...)
Anonymous
Japan/Hong Kong: Oh I like it very very much and think it?s a good pairing which I might actually ship if China stopped stealing Japan away.
Whale/Tony: That is?a ship? O_O
Belarus/Liechtenstein: Hmm, personally I think it could be cool. I don?t know, I?ll prefer Belarus with Hungary and Liechtenstein with Belgium I guess, but I think it?s an interesting pair.
Russia/America: Ohhh, I do ship this pair, somewhat, kind of. I mean, it?s an ?okay? pair in my books - if done properly, I guess. I think both characters actually do complement each other a lot.
Comprehending the terms of the financial loans, from the desire price to the time of repayment will support you decide whether or not this financial loan is proper for you. The fascination prices for negative credit score payday financial loans are considerably higher than typical loans.
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In the 8th edition of McCall?s Cooking School, which was published in 1981, an advertisement for Wyler?s Bouillon cubes presented a rice and gravy recipe. Despite its simplicity, the gravy calls for ingredients that put a dent in your diet and health. Here is a better, vegan alternative to gravy that keeps the creamy, buttery goodness without all the preservatives, simple starches, and hydrogenated fats.
Most bullion cubes are high in sodium and contain monosodium glutamate (MSG). One cube has nearly 600 milligrams of sodium and MSG is a potentially dangerous additive that can cause an host of symptoms, such as heart palpitations, headaches, and numbness. There is often a large amount of preservatives in bouillon cubes as well.
And while margarine is a cheaper substitute for butter, it?s a fat you should steer clear of. During its production, vegetable oils are heated at levels that completely destroy antioxidants in the oils and virtually make them them cancerous. Then the margarine is hydrogenated, using hazardous chemicals that remain in finished product as well as create fat molecules that are unnatural and unknown by the human metabolism. White flour is also an empty substance in the human body and is hard for it to process.
We can do better. By keeping the ingredients real, we take one step, but by keeping them vegan, we go a mile. Here?s a vegan gravy recipe that?ll satisfy even the most skeptical of palettes.
Vegan Gravy
Ingredients:
1.5 cups crimini mushrooms, chopped
1/2 tablespoon vegan butter (Earth Balance)
1/2 teaspoon sea salt
1/2 teaspoon black pepper
1.5 tablespoons vegan butter (Earth Balance)
1 tablespoon whole-wheat flour
1 tablespoon nutritional yeast
1 cup almond milk (or any other vegan milk)
1/2 cup white wine
1 tablespoon soy sauce
2 teaspoons dried thyme
Fresh thyme for garnish
Directions:
In a medium saucepan over medium heat, melt the 1/2 tablespoon of butter and add the crimini mushrooms, salt, and pepper. Stir and cook down until the volume has reduced and the liquid from the mushrooms is cooked off.
In a separate pot over medium heat, melt the 1.5 tablespoons of butter, add to it the flour and nutritional yeast, and stir until evenly combined. This will prevent clumping later. Next add the milk, wine, and soy sauce. Reduce the heat to medium-low and continuously stir until the mixture thickens.
When the mixture thickens to desired consistency ? it should drip in clumps, not drizzle, from a spoon ? add the cooked mushrooms and dried thyme. Stir over medium-low heat for 1-2 more minutes.
Garnish with fresh thyme and serve aside rice or whatever you?d like.
Bon Appetit!
Images: JB Curio, Aylin Erman
Aylin Erman currently resides in Istanbul and is creator of plant-based recipe website GlowKitchen.
Food ? Big brands says their mid-calorie goodies cut down on what?s bad for you.
New York ? Nonfat cheese that tastes like plastic. Low-calorie soda that leaves a bitter aftertaste. Sugar-free brownies that crumble like Styrofoam.
Dieters have learned an important lesson. When you take the fat and calories out of your favorite treats, you sometimes have to say goodbye to the taste, too.
But snack brands such as Dreyer?s/Edy?s ice cream, Hershey?s chocolate and Lay?s potato chips are trying to solve this age-old dieter?s dilemma by rolling out mid-calorie goodies that have more fat and calories than the snacks of earlier diet crazes but less than the original versions. They?re following the lead of soda companies such as Pepsi and Dr Pepper that introduced mid-calorie drinks last year.
It?s hard to isolate sales of mid-calorie snacks because they also usually have reduced fat, or other healthy attributes such as reduced sodium. But sales of all foods and drinks in which the amount of things such as fat, sugar, salt, carbohydrates have been actively reduced during production have risen 16 percent to $51.72 billion since 2006, according to research firm Euromonitor International.
The mid-calorie trend is hitting at a time when companies that make sugary and salty treats are being blamed for the country?s expanding waistlines. The problem is that the same things that make snacks taste good ? sugar, salt, calories ? also make them fattening. And many Americans don?t want to sacrifice taste at snack time. Shaving a few calories enables companies to market their cakes, cookies and chips as healthier without the stigma of bad taste that goes along with some low-fat products.
The mid-calorie trend is a toned-down version of the "light" craze that started in the 1990s. Back then, "low fat" or "no fat" was all the rage. But the products often fizzled.
For instance, McDonald?s rolled out the McLean Deluxe, a low-fat burger, in 1991. But the burger, which was made with seaweed, had dismal sales. It disappeared from restaurants within five years.
Similarly, Lay?s in 1998 introduced Wow fat-free potato chips that use fat substitute Olestra. But the ick factor trumped healthiness when the Food and Drug Administration said the chips had to come with a warning that Olestra may cause abdominal cramping, loose stools, and that it inhibits the absorption of some vitamins and other nutrients.
The FDA dropped the requirement for the label in 2004 after studying the matter. The chips were renamed "Light," but sales have not recovered.
The new era of diet food started in the past decade. In 2007, companies began offering 100-calorie packs of popular snacks like Oreos cookies and Twinkies cakes. That?s when brands started putting their focus on reducing calories ? without any flavor change.
story continues below
Reducing a nominal number of calories in your diet each day ? even from that morning coffee run or afternoon visit to the vending machine for chips ? is an effective way to battle obesity, says David Levitsky, professor of nutritional sciences at Cornell University.
But in order for that to work you have to eat the snacks in moderation. "If consumption of ice cream and potato chips does not increase and people eat somewhat better versions, the outcome will be good," Brownell says.
First, companies have to convince dieters that their mid-calorie snacks are not only healthy, but tasty, too.
With that in mind, Hershey?s in June introduced Simple Pleasures, chocolate with 30 percent less fat. A serving size of six pieces equals 180 calories and 8 grams of fat ? that?s 30 calories and 5 grams of fat less than the original Hershey?s chocolate bar. The company is hoping the deficit is enough to lure chocolate lovers who want to eat healthier.
Similarly, Lay?s in July rolled out two new flavors of its Kettle Cooked potato chips with 40 percent less fat. The brand, which fries chips in small batches so as to use less oil than the continuous frying process for regular chips, introduced "Applewood Smoked BBQ" and "Sun-Dried Tomato and Parmesan."
The company says it was able to lower the calories and fat without sacrificing taste. Regular Kettle Cooked chips have 160 calories and 9 grams of fat, while the reduced-fat versions have 130 calories and 6 grams of fat.
Copyright 2012 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
British people have long bemoaned the gradual encroachment of Americanisms into everyday speech, via Hollywood films and sitcoms. Now, "Britishisms" are crossing the pond the other way, thanks to the growing online popularity of British media such as Harry Potter, Downton Abbey and The Daily Mail.
For example, BBC News reports that "ginger" as a descriptor of a red-haired, freckly person has shot up in usage in the United States since 1998. That's the year the first Harry Potter book, with its Weasley family of gingers, hit store shelves. The trend shows up in Google ngram searches, which track the frequency of words and phrases appearing in print.
The Britishism invasion also includes "cheeky,"?"twee," "chat-up,"?"sell-by date" and "the long game," as well as "do the washing up," "keen on," "bit" (as in "the best bit"), "to book" (e.g. a flight), "called X" (instead of "named X") and "to move house."
A few of these now sound so familiar to American ears that their recent Limey origins might come as a surprise. [Why Do Americans and Brits Have Different Accents?]
While some of these British terms have gained ground because they sound pleasantly posh to American ears, Jesse Sheidlower, American editor-at-large of the Oxford English Dictionary, says others simply fill a gap where there is no equivalent in American English. "One-off," as in something which is done, or made, or which happens only once, and "go missing," instead of the vaguer "disappear," are two examples.
According to Sheidlower, the small but noticeable increase in the American usage of traditionally British terms doesn't bother Americans nearly as much as Americanisms bother many Brits.
"In the U.K., the use of Americanisms is seen as a sign that culture is going to hell," he told BBC News. "But Americans think all British people are posh, so ? aside from things that are fairly pretentious ? no-one would mind."
This laissez-faire linguistic attitude hasn't always been the American way. Early in U.S. history, when the nation was striving to distinguish itself from its former landlords, the dictionary maker Noah Webster set about establishing a distinctly American form of English. Webster's legacy includes the lack of "u" in words like "color" and the "-er" ending in words like "center" ? spelling variants he viewed as superior to their British counterparts (colour and centre).
Some of the economical spellings Webster adopted, such as "public" instead of the British "publick," have since spread back to England. Clearly, in the continuously evolving languages of these transatlantic allies, there is give and take.
Follow Natalie Wolchover on Twitter @nattyover?or Life's Little?Mysteries @llmysteries. We're also on?Facebook?&?Google+.
Copyright 2012 Lifes Little Mysteries, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
The humble salad spinner is great for washing leaves of lettuce without bruising them, but according to Busty Girl Comics, a blog that chronicles the issues that come with being large-chested, it's also a great tool for cleaning bras that can easily get mangled in the washing machine.
Anyone who's shopped for bras or shopped for bras for a partner knows that those things can get pretty expensive, so it makes sense to take care of them so they'll last as long as possible. Apparently, all you need for a gentle wash is soap made for delicate items, like lingerie soap or baby shampoo, some warm water, and a salad spinner dedicated to the task. You can probably figure out the rest, but according to the reaction at Tumblr, it works like a charm, and other hand-wash delicates clean up nicely in a salad spinner as well. You can also pick up fabric bags to protect your delicates in the wash, but we can appreciate the ingenuity of this tip.
Here's an awesome bit of advice from CaratheBug... | Busty Girl Comics
Bring your friends for a free tennis lesson! A great time to sample tennis for 4-15 years old. Racquet supplied. Must wear sneakers. Reservations necessary at shippanracquetclub@aol.com
Taylor Kinney Beach Volleyball Olympics 2012 Jessica Ennis Oscar Pistorius Aliya Mustafina Kirk Urso London 2012 Javelin
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JCI early table of contents for September 24, 2012Public release date: 24-Sep-2012 [ | E-mail | Share ]
Contact: Jillian Hurst press_releases@the-jci.org Journal of Clinical Investigation
Small proteins in the cornea protect against bacterial infection
Exposed tissue surfaces, including skin and mucous membranes, are under constant threat of attack by microorganisms in the environment. The layer of cells that line these areas, known as epithelial cells, are the first line of defense against these pathogens, but the underlying molecular mechanisms that allow them to repel microbes are unknown. In this issue of the Journal of Clinical Investigation, researchers at the University of California, Berkeley, report that epithelial cells in the cornea, which is highly resistant to bacterial infection, express small antimicrobial peptides, portions of human cytokeratin 6A, that defend the eye against infection. Using mass spectrometry, Suzanne Fleiszig and colleagues determined that these peptides protect against multiple bacterial pathogens by preventing the bacteria from binding to the epithelial cells. Additionally, they found that mice lacking cytokeratin 6A were more susceptible to eye infections. In an accompanying commentary, Michael Zasloff of Georgetown University School of Medicine discusses the implications of these findings for the development of antimicorbial therapeutics.
TITLE:
Cytokeratins mediate epithelial innate defense through their antimicrobial properties
AUTHOR CONTACT:
Suzanne Fleiszig
University of California at Berkeley, Berkeley, CA, USA
View this article at: http://www.jci.org/articles/view/65380?key=44a31f9a7987a1f6fd5e
New insight into hyperporlactinemia-associated infertility
Hyperprolactinemia, the presence of abnormally high levels of the hormone prolactin, is a well-established cause of infertility in women in their 20s and 30s. This hormone imbalance is frequently associated with low levels of gonadotrophic-releasing hormone (GnRH), a lack of ovulation, and a decrease in menstruation; however, the molecular mechanisms by which excess prolactin causes infertility are unclear. In this issue of the Journal of Clinical Investigation, researchers led by Nadine Binart at the University of Paris report that high levels of prolactin block expression of kisspeptin, a protein hormone that induces secretion of GnRH. By administering kisspeptin, Binart and colleagues restored ovulation in mice with high levels of prolactin. In an accompanying article, Ursula Kaiser of Brigham and Women's Hospital in Boston discusses the implications of this research for the clinical treatment of infertility in patients with hyperprolactinemia.
TITLE:
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration
View this article at: http://www.jci.org/articles/view/64455?key=bfeda7b4e5e1fa11a4b3
GATA transcription factors regulate pancreas development
Type 1 diabetes is caused by the autoimmune destruction of insulin-producing pancreatic ? islets. Efforts to reverse the disease are focused on replacing these cells and current research is focused on identifying the factors that contribute to islet generation during embryonic development. In this issue of the Journal of Clinical Investigation two research teams led by Anabel Rojas at the Andalusian Center for Molecular Biology and Regenerative Medicine in Seville, Spain and Lori Sussel at Columbia University report that GATA4 and GATA6 transcription factors are required for development of the pancreas in mice. Mice deficient in both genes failed to develop a pancreas, exhibited hyperglycemia, and died shortly after birth, while mice deficient in only one of the genes had very minor defects. Mutations in GATA6 and GATA4 are frequently found in neonatal diabetic patients. In a companion commentary, Jorge Ferrer and colleagues at the Hospital Clinic of Barcelona, Spain discusses the transcriptional mechanisms that underlie pancreas formation and their relation to new regenerative therapies for type 1 diabetes.
TITLE:
GATA4 and GATA6 control mouse pancreas organogenesis
View this article at: http://www.jci.org/articles/view/65751?key=af40e461737fe0703fce
MicroRNA links oncogenic signaling pathways in glioblastoma
Glioblastomas, the most prevalent primary brain tumor, frequently exhibit alterations in a number of signaling pathways that promote growth and metastasis; however, targeting of single elements has been clinically disappointing as the cancer cells simply reduce their reliance on targeted pathway. In this issue of the Journal of Clinical Investigation researchers at the Zhongshan School of Medicine in Ghuangzhou, China report on a microRNA, miR-182, that links two oncogenic signaling pathways in glioblastoma. MicroRNAs are molecules that suppress the expression of target genes. Jun Li and colleagues found that miR-182 was over-expressed in human glioblastoma patients and was correlated with the hyperactivation of two different oncogenic signaling pathways. Expression of miR-182 repressed expression of multiple negative regulators of these pathways, leading to sustained activation and enhanced malignancy. In a companion commentary, Christine Eyler of Brigham and Women's Hospital in Boston and Jeremy Rich of the Cleveland Clinic discuss the necessity of identifying multiple molecular targets within a given cancer to develop effective therapies.
TITLE:
TGF-? induces miR-182 to sustain NF-?B activation in glioma subsets
AUTHOR CONTACT:
Jun Li
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, , CHN
View this article at: http://www.jci.org/articles/view/66058?key=e2a0f7a4caee9492bf27
###
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
JCI early table of contents for September 24, 2012Public release date: 24-Sep-2012 [ | E-mail | Share ]
Contact: Jillian Hurst press_releases@the-jci.org Journal of Clinical Investigation
Small proteins in the cornea protect against bacterial infection
Exposed tissue surfaces, including skin and mucous membranes, are under constant threat of attack by microorganisms in the environment. The layer of cells that line these areas, known as epithelial cells, are the first line of defense against these pathogens, but the underlying molecular mechanisms that allow them to repel microbes are unknown. In this issue of the Journal of Clinical Investigation, researchers at the University of California, Berkeley, report that epithelial cells in the cornea, which is highly resistant to bacterial infection, express small antimicrobial peptides, portions of human cytokeratin 6A, that defend the eye against infection. Using mass spectrometry, Suzanne Fleiszig and colleagues determined that these peptides protect against multiple bacterial pathogens by preventing the bacteria from binding to the epithelial cells. Additionally, they found that mice lacking cytokeratin 6A were more susceptible to eye infections. In an accompanying commentary, Michael Zasloff of Georgetown University School of Medicine discusses the implications of these findings for the development of antimicorbial therapeutics.
TITLE:
Cytokeratins mediate epithelial innate defense through their antimicrobial properties
AUTHOR CONTACT:
Suzanne Fleiszig
University of California at Berkeley, Berkeley, CA, USA
View this article at: http://www.jci.org/articles/view/65380?key=44a31f9a7987a1f6fd5e
New insight into hyperporlactinemia-associated infertility
Hyperprolactinemia, the presence of abnormally high levels of the hormone prolactin, is a well-established cause of infertility in women in their 20s and 30s. This hormone imbalance is frequently associated with low levels of gonadotrophic-releasing hormone (GnRH), a lack of ovulation, and a decrease in menstruation; however, the molecular mechanisms by which excess prolactin causes infertility are unclear. In this issue of the Journal of Clinical Investigation, researchers led by Nadine Binart at the University of Paris report that high levels of prolactin block expression of kisspeptin, a protein hormone that induces secretion of GnRH. By administering kisspeptin, Binart and colleagues restored ovulation in mice with high levels of prolactin. In an accompanying article, Ursula Kaiser of Brigham and Women's Hospital in Boston discusses the implications of this research for the clinical treatment of infertility in patients with hyperprolactinemia.
TITLE:
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration
View this article at: http://www.jci.org/articles/view/64455?key=bfeda7b4e5e1fa11a4b3
GATA transcription factors regulate pancreas development
Type 1 diabetes is caused by the autoimmune destruction of insulin-producing pancreatic ? islets. Efforts to reverse the disease are focused on replacing these cells and current research is focused on identifying the factors that contribute to islet generation during embryonic development. In this issue of the Journal of Clinical Investigation two research teams led by Anabel Rojas at the Andalusian Center for Molecular Biology and Regenerative Medicine in Seville, Spain and Lori Sussel at Columbia University report that GATA4 and GATA6 transcription factors are required for development of the pancreas in mice. Mice deficient in both genes failed to develop a pancreas, exhibited hyperglycemia, and died shortly after birth, while mice deficient in only one of the genes had very minor defects. Mutations in GATA6 and GATA4 are frequently found in neonatal diabetic patients. In a companion commentary, Jorge Ferrer and colleagues at the Hospital Clinic of Barcelona, Spain discusses the transcriptional mechanisms that underlie pancreas formation and their relation to new regenerative therapies for type 1 diabetes.
TITLE:
GATA4 and GATA6 control mouse pancreas organogenesis
View this article at: http://www.jci.org/articles/view/65751?key=af40e461737fe0703fce
MicroRNA links oncogenic signaling pathways in glioblastoma
Glioblastomas, the most prevalent primary brain tumor, frequently exhibit alterations in a number of signaling pathways that promote growth and metastasis; however, targeting of single elements has been clinically disappointing as the cancer cells simply reduce their reliance on targeted pathway. In this issue of the Journal of Clinical Investigation researchers at the Zhongshan School of Medicine in Ghuangzhou, China report on a microRNA, miR-182, that links two oncogenic signaling pathways in glioblastoma. MicroRNAs are molecules that suppress the expression of target genes. Jun Li and colleagues found that miR-182 was over-expressed in human glioblastoma patients and was correlated with the hyperactivation of two different oncogenic signaling pathways. Expression of miR-182 repressed expression of multiple negative regulators of these pathways, leading to sustained activation and enhanced malignancy. In a companion commentary, Christine Eyler of Brigham and Women's Hospital in Boston and Jeremy Rich of the Cleveland Clinic discuss the necessity of identifying multiple molecular targets within a given cancer to develop effective therapies.
TITLE:
TGF-? induces miR-182 to sustain NF-?B activation in glioma subsets
AUTHOR CONTACT:
Jun Li
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, , CHN
View this article at: http://www.jci.org/articles/view/66058?key=e2a0f7a4caee9492bf27
###
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
FRAMINGHAM, Mass. (AP) ? Staples is speeding up the closure of about 15 of its U.S. stores and plans to close 45 stores and some delivery businesses in Europe.
The office products company also says it will invest more in its online and mobile efforts and will expand the product assortment that it offers to its business customers.
Staples Inc. said Tuesday that these moves and other actions are part of a strategic plan to better serve customers' needs and accelerate growth.
Staples is trying to adapt to the evolving needs of its customers. Last month the company reported that its second-quarter net income fell as sales of computers, software, and basic office supplies softened. Computer sales have been pressured by the introduction to many offices of the computer tablet and other mobile devices. Traffic is also down at Staples' stores and Europe continues to be a weak spot.
The chain expects the U.S. store closings will result in a charge of about $35 million in the fourth quarter. For fiscal 2012, it anticipates about 30 U.S. store closings. Staples also expects 30 stores will be scaled down and stores being relocated.
In Europe, the store closures are expected to occur before the end of fiscal 2012. The company has also tapped John Wilson to serve as president of Staples Europe. Wilson succeeds Rob Vale, who is retiring.
The retailer says its U.S. retail and online businesses will now be run by Demos Parneros. Joe Doody will continue to lead the North American contract and Quill.com businesses, and will assume leadership of supply chain and customer service operations in North America.
Staples expects its actions to result in charges of $145 million to $195 million by the end of fiscal 2012. It also foresees a third-quarter goodwill impairment charge of $790 million to $850 million within its European retail and catalog businesses.
The company says it is still looking into additional operational and strategic opportunities for its European operations, which includes the potential sale of its European printing systems business. It anticipates taking a third-quarter charge of $15 million to $20 million as it classifies the European printing systems business as discontinued operations.
The chain will also take a charge of $20 million by fiscal 2012's end as it rebrands its Australian business.
The Framingham, Mass., company anticipates annual savings of about $250 million by the end of fiscal 2015.
Staples's stock slipped 5 cents to $12.30 in premarket trading. Its shares hit a 52-week low of $10.57 in late August and peaked for the year at $16.93 in March.
The company has stores in 26 countries in North and South America, Europe, Asia and Australia.
The Challenge: As we mentioned earlier this year, Pinterest has been captivating online users with its emphasis on engagement, content, and personalization. Now Volvo is taking to the Pinterest boards with a consumer-driven campaign designed to re-establish the company?s image. But can their campaign succeed in an unproven community-based social medium like Pinterest?
A study conducted with Pinterest users earlier this year provided several insights into user habits:
Over 20% of users purchase items they ?pin? on their boards.
Purchasers visit Pinterest 2.7 times more often and pin 3.1 times as many items as non-purchasers.
The 3 most popular words purchasers use to describe Pinterest are ?friendly,? ?community,? and ?genuine.?
The statistics demonstrate that not only does Pinterest usage drive sales, but that those sales are achieved almost entirely through user interaction.RJ Metrics correlated this by showing over 80% of images ?pinned? on Pinterest bulletin boards are re-pinned from other users.
Can companies penetrate such a tight-knit buying community without appearing intrusive?
Teresa Caro of iMediaConnection.com maintains that they can, if they create ?a balance between?genuine brand story and?content that inspires and compels action.?
One example of this formula in action is Volvo?s new Pinterest campaign. Joe Barbagallo, their Social Media Manager, says the company is ?rebranding [them]selves?through design. Pinterest being focused around photos and being driven by consumers is really what attracted us to establish a presence [there] .?
Volvo is basing the direction of the campaign on past social media successes such as their ?You Inside? Facebook campaign, which allows customers to create and relate their own experiences.
Volvo re-uses this formula on Pinterest, inviting users to describe their ideal ?joyride? by pinning images of the new Volvo S60 T5 and discussing their perfect road trip stories. And their commitment to customer interaction is getting them results.
KEY TAKEAWAYS FOR MARKETERS
1. Understand the nature of Pinterest before marketing. As an inherently visual social medium, it requires a means to generate strong visuals, as well as time to create relationships and generate strong customer engagement.
2. Give customers the ability to share their experiences the way they want to, not the way you want them to. As Mr. Barbagallo says, ?we want these people to experience the product on their own terms and speak about it as naturally and organically as they can.? Customers respond best when they?re allowed to give feedback their way.
3. Let your customers feel relevant. Engaging customers, sharing your story with them, and inviting them to do the same lets them know that they are important to you. And that lays the foundation for all good customer relationships.
Author: Ernan Roman???? Ernan Roman on the Web
About Ernan Roman Direct Marketing Corp., (ERDM):
ERDM provides Voice of Customer-driven Customer Experience Marketing consulting services for companies such as IBM, MassMutual, QVC, NBC Universal, Microsoft, Hewlett-Packard, and Symantec Corp. They have conducted over 9000 hours of in-depth interviews with customers and prospects of these clients to gain an in-depth? View?full?profile
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1 Hour Guided Hypnotic Meditation to Induce Sleep, Relieve Negativity and Stress
Headset or earphones highly recommended! This is a guided meditation by one of the nations leading hypnotherapist and seminar trainers who specializes in brain/mind technology. In this session you will be guide through with powerful key phases to generate a deep state of relaxation and an altered state of consciousness using your mind and ulta-powerful Zapper mind-programming combined with life changing suggestions. The Zapper is a composition of vibrational theta waves and a diminishing delta-level pulse. it generate an altered state of consciousness in which suggestions are delivered with 25 to 200 times the mind programming power of readily accepted suggestions. With continued subconscious reinforcement of this kind, your mind will manifest a change in belief. it is your beliefs that generate your thoughts and emoitions, which in turn create your experiences. The meditative level generated by the Zapper technology is the Level Albert Einstein claimed to have received his ideas and Mozart composed his music. FAIR USE NOTICE: This video may contain copyrighted material the use of which has not always been specifically authorized by the copyright owner. I am making such material available in my efforts to advance understanding of spiritual healing, human consciouness, spiritual awareness,scientific, and research, etc. I believe this constitutes a 'fair use' of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material in this video is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. Ranked 4.25 / 5 | 4556 views | 0 comments
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Hypnotic Video - Money Mentalism Video Series - EXPECT AMAZING RESULTS-Hypnosis/NLP/Subliminal
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Hypnotic Introduction - Hypnosis & NLP Across the Globe!
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How To Enhance Your Hypnotic Performance Magnetic Tonalities
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Delta Brainwaves for Self Hypnosis
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Relaxation with the Ocean for Meditation Hypnosis
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