রবিবার, ২৪ ফেব্রুয়ারি, ২০১৩

Battle for Syria's Aleppo airport intensifies

BEIRUT (AP) ? The battle for Syria's second-largest airport intensified Saturday as government troops tried to reverse recent strategic gains the rebels have made in the northeast in their quest to topple President Bashar Assad.

Assad's forces have been locked in a stalemate with rebels in Aleppo since July when the city, the largest in Syria, became a major battlefield in the 2-year-old conflict the United Nations says has killed at least 70,000 people. For months, rebels have been trying to capture the international airport, which is closed because of the fighting.

Rami Abdul-Rahman, director of the Britain-based Syrian Observatory for Human Rights activist group, said the current fighting was focused on a section of a highway linking the airport with Aleppo, the commercial hub of the nation.

The rebels have cut off the highway, which the army has been using to transport troops and supplies to a military base within the airport complex. Rebels have made other advances in the battle for the airport in recent weeks, including overrunning two army bases along the road to the airport.

The rebels also control large swaths of countryside outside Aleppo and whole neighborhoods inside the city, which is carved up into areas controlled by the regime and others held by rebels. Months of heavy street fighting has left whole neighborhoods of the storied city in ruins.

On Friday, regime forces fired three missiles into a rebel-held area in eastern Aleppo, hitting several buildings and killing 37 people, according to the Observatory. Some bodies were recovered from the rubble of apartments flattened in the strike, which apparently involved ground-to-ground missiles.

A similar attack on Tuesday in another impoverished Aleppo neighborhood killed at least 33 people, almost half of them children.

In Damascus, government forces shelled several rebellious suburbs Saturday as part of their efforts to dislodge opposition fighters who have used the towns and villages surrounding the capital as a staging ground for their attempts to push into the center of the city.

Recent rebel advances in the suburbs, combined with the bombings and three straight days of mortar attacks earlier this week, marked the most sustained challenge to the heart of Damascus, the seat of Assad's power.

A suicide car bombing on Thursday near the ruling Baath Party headquarters in central Damascus killed 53 people and wounded more than 200, according to state media. Anti-regime activists put the death toll at 61, which would make it the deadliest bombing of the revolt in the capital.

The different tolls could not be reconciled.

Nobody has claimed responsibility for the attack. Car bombs and suicide attacks have been a hallmark of Jabhat al-Nusra, an Islamic militant group that is one of the myriad factions fighting on the rebel side. Nusra fighters, the most effective group on the battlefield, have led assaults on military installations and control swaths of territory in the north, including parts of Aleppo.

The fighting has increasingly taken on sectarian overtones with members of Syria's Sunni Muslim majority dominating the rebel ranks, who are fighting Assad's regime that is mostly made up of Alawites, an offshoot Shiite group.

Efforts to stop the bloodshed in Syria so far have failed, leaving the international community at a loss of how to end the civil war.

Russia, one of Assad's closest allies, and the Arab League proposed on Wednesday to broker talks between the Syrian opposition and Assad's regime. Syrian Foreign Minister Walid al-Moallem will lead a delegation to Moscow on Monday, and Russia had been expecting a visit in March from opposition leader Mouaz al-Khatib.

Russian Foreign Minister Sergey Lavrov said the Kremlin and the League were trying to establish direct contact between the Syrian regime and the opposition. The Western-backed opposition umbrella group, the Syrian National Coalition, long rejected any talks as long as Assad remains in power.

In a sharp turnaround, al-Khatib said earlier this month he would meet with members of the regime if that would help end the bloodshed. His comments, however, drew pointed criticism from several opposition figures who said al-Khatib spoke for himself, not the group.

On Friday, the Coalition announced after two days of meetings in Cairo that it would welcome U.S. and Russian mediation to negotiate a peace deal to end the country's civil war but insisted it would not allow Assad or members of his security services to participate in the talks.

But the SNC then said in a statement posted on its Facebook page late Friday that its leaders would not travel to Washington or Moscow for any talks. It said the decision was taken to protest the international community's "silence over crimes committed by the regime" against Syrian people in Aleppo and other cities across the country.

The Coalition also lashed out at Russia, saying it bears "special responsibility" because it supplies the regime with weapons.

The statement also said that the opposition leaders would boycott a meeting next month in Rome of the Friends of Syria, which includes the United States and its European allies.

___

Associated Press writer Ryan Lucas in Beirut contributed to this report.

Source: http://news.yahoo.com/battle-syrias-aleppo-airport-intensifies-131106416.html

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Morning links: Tavon Austin's iPad prepares him for Patriots

Good morning, football fans. It's Manti Te'o day here at the combine, but before the craziness, let's pass along some links from today's Herald.

My main story is on West Virginia slot receiver Tavon Austin, who has studied Wes Welker for years and might be his suitable replacement.

Karen Guregian writes the Patriots can't afford to drop another draft card if they target a wide receiver.

My notebook leads with a look at the high draft value of injured South Carolina running back Marcus Lattimore, a star who has met with the Patriots. There are also items on former Patriot Brent Williams' son, Ja'Rick Rogers' penance and Rob Gronkowski's spiked performance.

Source: http://bostonherald.com/sports/patriots_nfl/the_blitz/2013/02/morning_links_tavon_austins_ipad_prepares_him_for_patriots

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Afghanistan: U.S. special forces must leave province

KABUL, Afghanistan (AP) ? Afghanistan's president on Sunday ordered all U.S. special forces to leave a strategically important eastern province within two weeks because of allegations that Afghans working with them are torturing and abusing other Afghans.

The decision seems to have caught the coalition and U.S. Forces Afghanistan, a separate command, by surprise. Americans have frequently drawn anger from the Afghan public over issues ranging from Qurans burned at a U.S. base to allegations of civilian killings.

"We take all allegations of misconduct seriously and go to great lengths to determine the facts surrounding them," the U.S. forces said in a statement.

Also Sunday, a series of attacks in eastern Afghanistan showed insurgents remain on the offensive even as U.S. and other international forces prepare to end their combat mission by the end of 2014.

Suicide bombers targeted Afghanistan's intelligence agency and other security forces in four coordinated attacks in the heart of Kabul and outlying areas in a bloody reminder of the insurgency's reach nearly 12 years into the war.

Presidential spokesman Aimal Faizi said the decision to order the American special forces to leave Wardak province was taken during a meeting of the National Security Council because of the alleged actions of Afghans who are considered linked to the U.S. special forces.

He said all special forces operations were to cease immediately in the restive province next to Kabul, which is viewed as a gateway to the capital and has been the focus of counterinsurgency efforts in recent years.

The Taliban have staged numerous attacks against U.S.-led coalition forces in the province. In August 2011, insurgents shot down a Chinook helicopter, killing 30 American troops, mostly elite Navy SEALs, in Wardak. The crash was the single deadliest loss for U.S. forces in the war.

Afghan forces have taken the lead in many such special operations, especially so-called night raids.

"Those Afghans in these armed groups who are working with the U.S. special forces, the defense minister asked for an explanation of who they are," Faizi said. "Those individuals should be handed over to the Afghan side so that we can further investigate."

A statement the security council issued in English said the armed individuals have allegedly been "harassing, annoying, torturing and even murdering innocent people."

Ceasing all such operations could have a negative impact on the coalition's campaign to go after Taliban leaders and commanders, who are usually the target of such operations.

Faizi said the issue had already been brought up with the coalition.

The U.S. statement said only that the announcement was "an important issue that we intend to fully discuss with our Afghan counterparts. But until we have had a chance to speak with senior Government of the Islamic Republic of Afghanistan officials about this issue, we are not in a position to comment further."

The brazen assaults, which occurred within a three-hour timespan, were the latest to strike Afghan forces, who have suffered higher casualties this year as U.S. and other foreign troops gradually take a back seat and shift responsibility for security to the government.

The deadliest attack occurred just after sunrise ? a suicide car bombing at the gate of the National Directorate of Security compound in Jalalabad, 125 kilometers (78 miles) east of Kabul.

Guards shot and killed the driver but he managed to detonate the explosives-packed vehicle, killing two intelligence agents and wounding three others, according to a statement by the intelligence agency. Provincial government spokesman Ahmad Zia Abdulzai confirmed the casualty toll and said the building was damaged in the attack.

A guard also shot and killed a man in an SUV filled with dynamite that was targeting an NDS building on a busy street in Kabul, not far from NATO headquarters. The explosives in the back of the vehicle were defused. Blood stained the driver's seat and the ground where security forces dragged out the would-be attacker.

Shortly before the Jalalabad attack, a suicide attacker detonated a minivan full of explosives at a police checkpoint in Pul-i-Alam on the main highway between Kabul and Logar province. One policeman was killed and two others were wounded, along with a bystander, according to the NDS.

Also in Logar province, which is due south of Kabul, a man wearing a suicide vest was stopped by police as he tried to force his way into the police headquarters for Baraki Barak district, said Din Mohammad Darwesh, the provincial government spokesman. The attacker detonated his vest while being searched, wounding one policeman, according to Darwesh and the NDS.

Taliban spokesman Zabiullah Mujahid claimed responsibility for the Jalalabad attack and two others in the eastern province of Logar in an email to reporters. He did not address the attempted assault in Kabul.

____

Associated Press writers Heidi Vogt, Rahim Faiez and Kim Gamel contributed to this report from Kabul.

Source: http://news.yahoo.com/afghanistan-us-special-forces-must-leave-province-161601103.html

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Bank of Japan contest becoming more open race as Muto loses momentum

TOKYO (Reuters) - Former top bureaucrat Toshiro Muto is losing some momentum in the race to become Japan's next central bank governor, making for a more open contest, which will kick off in full force this week following Prime Minister Shinzo Abe's return from his U.S. trip.

Muto had been considered the leading candidate to replace incumbent Masaaki Shirakawa, who leaves on March 19 after a five-year term. Muto remains on the short list with strong backing from bureaucrats at the powerful Ministry of Finance.

But evidence is building that the race may be closer than previously thought between Muto, Asian Development Bank President Haruhiko Kuroda and former deputy governor Kazumasa Iwata, say officials and lawmakers familiar with the selection process.

Abe, who won a resounding election victory in December promising to finally rid Japan of nearly 20 years of deflation, wants a fresh face in the job, someone more eager to experiment with radical measures, the sources said.

"Muto is preferred by finance ministry bureaucrats, while people close to Abe want someone else," said one of the sources, who spoke on condition of anonymity due to the sensitivity of the matter.

"How markets may react is also important," the source said, adding that Abe may want to avoid disappointing markets already pricing in a radical makeover of monetary policy under a new Bank of Japan (BOJ) leadership. His policy prescription, dubbed "Abenomics", has pushed the yen to its lowest level in more than three years.

Tokyo share prices fell briefly after Reuters reported on February 15 that Muto was leading the BOJ race, as investors saw him as a policymaker who would be more aggressive with policy than the outgoing Skirakawa, but who would also refrain from the more unorthodox steps advocated by some candidates.

Finance Minister Taro Aso told reporters on Friday the new BOJ governor does not necessarily have to be someone from his ministry, leaving room to support candidates besides Muto if Abe insists on someone more radical.

Abe hardened his comments last week on the need for a new governor to have international contacts as a key qualification for the post, suggesting that he prefers someone with experience in financial diplomacy. Muto spent most of his career in domestic affairs, rising up the career ladder at the ministry of finance to become its top bureaucrat.

"Japan now needs a governor who can join, communicate and convince people in the inner circles of global finance," Abe told parliament on Wednesday.

CHOICES

That would put ADB's Kuroda, who was Japan's top currency diplomat in the midst of the Asian financial crisis in the late 1990s, at the top of the list. As president of the 67-member ADB, which includes countries from outside of Asia, he rubs shoulders with policymakers the world over.

Kuroda is now leading the race to become nominated by the government as next BOJ governor, the major Japanese daily Asahi newspaper reported on Saturday, quoting finance ministry and senior government officials.

Indeed, Kuroda ticks many other qualifications suggested by Abe's cabinet ministers and opposition parties, such as experience managing a large organization, strong English skills and the sharing of Abe's calls for bolder monetary stimulus.

Kazumasa Iwata, a former deputy BOJ governor, also remains a strong candidate thanks to his fluent English, academic work on economic policy known at home and abroad, and his consistent calls for more aggressive bond buying by the central bank.

But both of them face road-blocks in getting chosen. Kuroda would have to cut short his job at the ADB, which could weaken Japan's standing as the country that traditionally provides the head of the organization established in 1966.

Should Iwata get the top job, his repeated calls for the BOJ to create a fund to buy foreign bonds could raise suspicions among Japan's Group of Seven peers that Tokyo is targeting the yen with monetary policy.

More radical candidates from the academia like Kikuo Iwata and Takatoshi Ito, while favored by Abe and his aides, may have less of a chance because they lack experience managing a big organization -- a prerequisite set by Aso, the sources said.

The selection process for the top BOJ posts -- that of the governor and two deputy governors -- will start in full force later on Sunday upon Abe's return from the United States.

"The choice will have a huge impact on the current market trend of yen weakness and share price gains. It will be made based mainly on whether the person will pursue bold monetary policy that the premier is seeking," Japan's top government spokesman Yoshihide Suga told a television program on Sunday.

Delicate political maneuvering is still needed to ensure parliamentary approval and may mean that Abe has to settle for someone who is not his first choice.

The prime minister is keen to avoid a rerun of the debacle in 2008 when the seat for the BOJ governor was left open for weeks because the main opposition Democratic Party of Japan (DPJ) blocked the nomination of several candidates, including Muto, in the upper house.

Support from opposition parties is vital again as Abe's ruling Liberal Democratic Party lacks a majority in the upper house. The chance of Muto getting the job heightens if Abe can garner support from the biggest opposition Democratic Party of Japan, which has signaled it would not rule out ex-bureaucrats.

But other candidates will have a better chance if Abe must rely on support from fringe parties like Your Party, which is opposed to ex-bureaucrats and want the governor to be a fluent English speaker, which Muto is not.

"Abe may have already chosen his top candidate, but nobody really knows what's on his mind. Everything will start rolling once he's back from the United States," said another source.

(Additional reporting by Sumio Ito, Yoshifumi Takemoto, Shinji Kitamura and Yuko Yoshikawa; Editing by Neil Fullick)

Source: http://news.yahoo.com/bank-japan-contest-becoming-more-open-race-muto-012126520--business.html

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শনিবার, ২৩ ফেব্রুয়ারি, ২০১৩

In U.S., flu vaccine worked in just over half of those who got it

CHICAGO (Reuters) - A U.S. government analysis of this season's flu vaccine suggests it was effective in only 56 percent of people who got the shot, and it largely failed to protect the elderly against an especially deadly strain circulating during flu season.

The U.S. Centers for Disease Control and Prevention said the findings underscore the need for more effective weapons in the fight against influenza, which kills between 3,000 and 50,000 people in the United States each year depending on the severity of the flu season.

"We simply need a better vaccine against influenza, one that works better and lasts longer," CDC Director Dr. Thomas Frieden said in a statement on Thursday.

Experts generally estimate the effectiveness of flu vaccines to be between 50 percent and 70 percent, but this vaccine appears to have fallen on the low side of that range.

The vaccine did cut the risk of medical visits caused by either influenza A or influenza B by 56 percent, according to the study published in the CDC's Morbidity and Mortality Weekly Report.

It was more effective against influenza B, protecting 67 percent of those who were vaccinated. Against the influenza A (H3N2) strain, the vaccine protected only 47 percent.

The protective benefits of the vaccine against influenza B were consistent across age groups. That was not the case with the influenza A (H3N2) component of the vaccine, which protected 46 percent to 58 percent of people aged 6 months to 64 years, but only 9 percent of those 65 and older, a finding that was statistically insignificant.

The estimates are based on studies of 2,697 children and adults enrolled in the U.S. Influenza Vaccine Effectiveness Network between December 3 and January 19. The CDC said those estimates may change by the end of the flu season, when more people have been sampled.

Even so, the findings suggest that a large group of elderly people, who are consistently the most vulnerable to influenza, were unprotected during this year's flu season.

POOR IMMUNE RESPONSE TO VACCINES

One possible explanation may be that in older individuals, the immune system often produces a less robust immune response to vaccines, or to any infection.

CDC experts suggested that poor immune response to the influenza A (H3N2) component of the vaccine may help explain why the elderly were not protected, but said in the report the findings "should not discourage future vaccination by persons aged 65 years (or older), who are at greater risk for more severe cases and complications from influenza."

Dr. Joseph Bresee, a flu expert at the CDC, said overall the vaccine worked "OK," but it is not fully clear why people over 65 responded poorly.

"Part of it is they are elderly and they respond less vigorously to vaccines. But it appears that some of the people, at least, developed a less robust response to this particular antigen," he said, referring to the H3N2 component of the flu vaccine.

"Why that is, I don't think we know yet. We're looking at it closely," he said.

Bresee said most of the elderly in the study took conventional flu vaccine, and not the high-dose version developed by vaccine giant Sanofi to address issues of poor immune responses in the elderly.

"We'd love to be able to look at the question of whether it is actually more effective or not. We just don't have enough use yet," he said.

Sanofi said it shipped 6 million doses of the special formulation for the elderly, but it did not have information on how many of the doses were used, or whether any had been used by patients in the study.

What is clear, Bresee said, is the need for the elderly who get sick with flu symptoms to seek treatment with antiviral medications, such as Roche Holding Ag's Tamiflu, which can reduce the severity of their illness.

CDC noted that vaccine effectiveness has been known to vary based on a number of factors including virus type, age, the particular flu season and variations in an individual's immunity.

"Although it's far from perfect, flu vaccination is by far the best tool we have to protect from flu," Frieden said.

BETTER VACCINES

Frieden said the U.S. Department of Health and Human Services as well as pharmaceutical companies are working to produce better vaccines. Efforts include the use of genetic engineering to develop more potent and more modern flu vaccines, with the hope of ultimately developing a universal flu vaccine that could protect against all strains of flu. Experts predict that could be possible within eight to 10 years.

"It's going to be hard but it's well worth the effort," Frieden said.

Already there are signs of change. In November, the Swiss drugmaker Novartis won U.S. Food and Drug Administration approval for Flucelvax, a seasonal flu vaccine grown in animal cell cultures instead of live chicken eggs, a speedier and more reliable process that could help build stockpiles in the event of a pandemic.

In December, GlaxoSmithKline won FDA approval for a new seasonal flu shot called Fluarix that protects against four strains of seasonal flu - known as a quadrivalent vaccine - instead of three strains, known as a trivalent vaccine. The announcement followed the approval last February of AstraZeneca's four-strain flu nasal spray made by the company's MedImmune unit. Current vaccines tackled two A strains and one B strain. The quadrivalent vaccines will add an additional B strain.

Last month, the FDA approved the first gene-based flu vaccine developed by privately held Protein Sciences Corp, which uses genetic engineering to grow portions of the virus in insect cells.

"What we're looking at is really incremental improvements, because if we could make the breakthrough improvements easily it would have happened already," Dr. Leonard Friedland, vice president of clinical and medical affairs for vaccines in North America at GlaxoSmithKline, said in an interview last month.

Glaxo's Fluarix is the first inactivated flu shot to include four instead of three strains of flu.

"It was just licensed and will be available for next season," Friedland said, noting that Sanofi is also in the process of having their four-strain flu vaccine approved.

AstraZeneca's FluMist, a live, attenuated or weakened flu vaccine, will also have a four-strain version available for next flu season.

Dr. Chris Ambrose, a vice president at AstraZeneca's MedImmune unit, said the company plans to completely switch to the four-strain version of Flumist.

Sanofi Spokeswoman Donna Cary said the company has produced flu vaccines for specific age groups, including its high dose vaccine for the elderly.

"The next step for the future is to get to the point where we don't need to develop a new vaccine every year," Cary said. "The main thing we are all looking forward to is the universal vaccine."

(Additional reporting by Bill Berkrot in New York; Editing by Mohammad Zargham)

Source: http://news.yahoo.com/flu-vaccine-worked-just-over-half-americans-got-191418100--finance.html

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শুক্রবার, ২২ ফেব্রুয়ারি, ২০১৩

Schenkkan, O'Brien win award honoring Sen. Kennedy

This theater image released by Columbia University shows Jack Willis as Lyndon Johnson, left, and Kenajuan Bentley as the Rev. Martin Luther King Jr. in a scene from "All The Way" by Robert Schenkkan. Schenkkan?s ?All the Way? have been named the inaugural winners of a theater award honoring the late Sen. Edward Kennedy. Columbia University on Friday said both playwrights will get the award as well as $100,000 each, one of the largest prizes given for dramatic writing. (AP Photo/Columbia University, Jenny Graham)

This theater image released by Columbia University shows Jack Willis as Lyndon Johnson, left, and Kenajuan Bentley as the Rev. Martin Luther King Jr. in a scene from "All The Way" by Robert Schenkkan. Schenkkan?s ?All the Way? have been named the inaugural winners of a theater award honoring the late Sen. Edward Kennedy. Columbia University on Friday said both playwrights will get the award as well as $100,000 each, one of the largest prizes given for dramatic writing. (AP Photo/Columbia University, Jenny Graham)

This theater image released by Portland Center Stage via Columbia University shows Danny Wolohan as Dan O'Brien, left, and William Salyers as Paul Watson during a performance of "The Body of an American" by Dan O'Brien. O?Brien?s ?The Body of an American? and Robert Schenkkan?s ?All the Way? have been named the inaugural winners of a theater award honoring the late Sen. Edward Kennedy. Columbia University on Friday said both playwrights will get the award as well as $100,000 each, one of the largest prizes given for dramatic writing. (AP Photo/Portland Center Stage via Columbia University, Patrick Weishanpel)

This undated image released by Columbia University shows playwright Dan O'Brien. O?Brien?s ?The Body of an American? and Robert Schenkkan?s ?All the Way? have been named the inaugural winners of a theater award honoring the late Sen. Edward Kennedy. Columbia University on Friday said both playwrights will get the award as well as $100,000 each, one of the largest prizes given for dramatic writing. (AP Photo/Columbia University, David Bornfriend)

(AP) ? Dan O'Brien's "The Body of an American" and Robert Schenkkan's "All the Way" have been named the inaugural winners of a theater award honoring the late U.S. Sen. Edward Kennedy.

Columbia University on Friday said the playwrights will share the award and $100,000, one of the largest prizes given for dramatic writing.

The Edward M. Kennedy Prize for Drama Inspired by American History honors a new play or musical that explores the United States' past and deals with great issues of the day.

The play by Schenkkan, who won the Pulitzer Prize for Drama for "The Kentucky Cycle," begins in November 1963 with Lyndon B. Johnson's sudden ascension to the presidency following the assassination of Kennedy's older brother John F. Kennedy and ends 12 months later with Johnson's historic landslide victory over Barry Goldwater. "All the Way" premiered at the Oregon Shakespeare Festival in 2012.

O'Brien's play is a story of war and war reporting that was inspired by the experiences of Paul Watson, who won a Pulitzer for a 1993 photo of a dead U.S. Army Ranger dragged through the streets of Somalia's capital. It premiered at Portland Center Stage last year.

The other finalists were "Hurt Village," by Katori Hall; "Party People," by the performance group Universes; and "Rapture, Blister, Burn," by Gina Gionfriddo.

The prize was established by Kennedy's sister Ambassador Jean Kennedy Smith in consultation with playwright Tony Kushner. It will be announced each year on Feb. 22, the anniversary of Kennedy's birth. The Massachusetts senator died of cancer in 2009.

Plays and musicals that received their first professional productions in 2012 were eligible for the prize. The winners were selected by a panel of nine judges that included playwrights Lynn Nottage, Itamar Moses, Diana Son and Brian Yorkey and Columbia University President Lee C. Bollinger.

___

Online: http://kennedyprize.columbia.edu

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-02-22-Kennedy%20Drama%20Prize/id-a3f4e161825d48e88c15e9ad8d0b7114

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Effectiveness of magnetic device for treatment of reflux disease demonstrated

Feb. 22, 2013 ? A study published Feb. 21 in the New England Journal of Medicine (NEJM) provides clinical evidence of the safety and effectiveness of a new magnetic medical device to treat gastroesophageal reflux disease (GERD). Santiago Horgan, MD, professor of surgery at the University of California, San Diego School of Medicine and study co-author, was the first surgeon in the United States to implant the FDA-approved device.

"What we found is that the LINX magnetic device can solve GERD's underlying problem, a weak spincter," said Horgan, chief of minimally invasive surgery, UC San Diego Health System. "The device corrects an anatomical defect that allows acids to move up the throat. For my patients this has been an effective way to permanently treat this painful condition, improve their quality of life, and end the need for over-the-counter medications."

The LINX system is composed of a series of titanium beads, each with a magnetic core, that are connected to form a ring shape. It is implanted at the lower esophageal sphincter (LES), a circular band of muscle that closes the last few centimeters of the esophagus and prevents the backward flow of stomach contents.

As reported in the study, after sphincter augmentation with the LINX System, the majority of patients were able to substantially reduce or resolve their reflux symptoms, while eliminating use of their reflux medications such as proton pump inhibitors. Severe regurgitation was eliminated in 100 percent of patients, and nearly all patients (93 percent) reported a significant decrease in the need for medication. More than 9 in 10 patients (94 percent) reported satisfaction with their overall condition after having the LINX System, compared to 13 percent before treatment while taking medication.

Horgan said the device is an alternative to Nissen fundoplication which involves irreversibly wrapping the stomach around the esophagus. The LINX System allows surgeons to leave the stomach intact and support the weak sphincter with a small device that can be removed.

More than 20 percent of the U.S. population experiences the painful burning symptoms of GERD. For these 20 million Americans, the first line of defense is medication. GERD can cause both pain and injury to the esophageal lining and may lead to a precancerous condition called Barrett's esophagus. Symptoms of GERD include heartburn and regurgitation, often associated with the inability to sleep and dietary constraints.

The LINX system was studied in a controlled, prospective, multicenter trial involving 14 U.S. and European medical centers as part of the FDA approval process. The patients in the study reported suffering from reflux symptoms for a median of 10 years and taking reflux medications for a median of five years.

The LINX? Reflux Management System is manufactured by Torax Medical which funded the study.

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Story Source:

The above story is reprinted from materials provided by University of California, San Diego Health Sciences.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Robert A. Ganz, Jeffrey H. Peters, Santiago Horgan, Willem A. Bemelman, Christy M. Dunst, Steven A. Edmundowicz, John C. Lipham, James D. Luketich, W. Scott Melvin, Brant K. Oelschlager, Steven C. Schlack-Haerer, C. Daniel Smith, Christopher C. Smith, Dan Dunn, Paul A. Taiganides. Esophageal Sphincter Device for Gastroesophageal Reflux Disease. New England Journal of Medicine, 2013; 368 (8): 719 DOI: 10.1056/NEJMoa1205544

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Z-70c8g6y4E/130222143138.htm

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